The headlines led with a 22,000-litre tank and a 99% cost drop. Here is a bioreactor engineer’s read on what Parima and Vow actually proved, why the media breakthrough matters more than the vessel, and the quiet shift that turned cultivated meat into a fermentation problem.
What happens when a bioreactor engineer points his state-estimation toolkit at football. Model90 is a statistical forecasting engine for the 2026 World Cup and the major leagues, built on Dixon-Coles Poisson, Elo, xG and a calibrated meta-model. An honest look at how it works and what its Brier score really means.
A Python CLI tool that strips background noise from any video file using ML denoisers — while copying the video stream byte-for-byte. A 6 GB 4K file processes in minutes instead of hours.
I rebuilt two published CHO cell-culture papers — a hybrid ODE + machine-learning growth model, and a genome-scale metabolic reduction pipeline — as an interactive digital twin that runs in the browser. Here’s how it works, what’s under the hood, and an honest take on what it’s good for. No hosted version yet; the code is on GitHub and a live instance is coming soon.
If you’ve ever read a paper on lysine production with Corynebacterium glutamicum and thought “right, but what do I actually do on Monday morning when I’m standing in front of the bioreactor” — this post is for you. I’m going to walk through the entire process of setting up and running a 5L bench-scale fed-batch… Read More: Running a 5-Litre Lysine Fermentation From Scratch. Everything Nobody Tells… »
Why Trastuzumab Is the Perfect Test Case When I built my antibody developability predictor, I knew I needed to validate it against a molecule where we actually know the manufacturing story. Trastuzumab (Herceptin) was the obvious choice. It’s one of the most successful therapeutic antibodies ever made, with decades of manufacturing data behind it. More… Read More: Case Study: Predicting Trastuzumab Developability »
I Built a Game Where You Can Watch AI Think (And It’s Weirdly Satisfying) You know that feeling when you’re trying to learn something new and the teacher just says “trust me, it works”? Yeah, I hate that too. So I built a game that does the opposite. It’s a little AI agent learning to… Read More: AI Brain Demo For Fun »
The Inflection Point Three-four years ago, I stood in front of production equipment I’d designed using textbook equations and decades-old heuristics. The systems worked—they always had—but I couldn’t shake the feeling that we were leaving performance on the table. That nagging intuition led me down a rabbit hole of machine learning papers, Python tutorials, and… Read More: From Conventional Design to AI-Driven Innovation: A Strategic Journey in… »