Tag Archives: Bioprocess Engineering

A Tonne of Duck in One Run: What Parima and Vow Actually Proved

By | July 18, 2026

The headlines led with a 22,000-litre tank and a 99% cost drop. Here is a bioreactor engineer’s read on what Parima and Vow actually proved, why the media breakthrough matters more than the vessel, and the quiet shift that turned cultivated meat into a fermentation problem.

When the Steel Outlives the Startup: Inside UPSIDE’s $50M Bid for Believer Meats

By | June 19, 2026

UPSIDE Foods has bid $50 million for Believer Meats’ North Carolina plant. The interesting question isn’t the price — it’s which parts of a dead cultivated-meat company are actually worth buying: the steel, the biology, or the process intelligence.

From Lab Bench to Browser: A Hybrid Digital Twin for CHO Cell Culture

By | May 30, 2026

I rebuilt two published CHO cell-culture papers — a hybrid ODE + machine-learning growth model, and a genome-scale metabolic reduction pipeline — as an interactive digital twin that runs in the browser. Here’s how it works, what’s under the hood, and an honest take on what it’s good for. No hosted version yet; the code is on GitHub and a live instance is coming soon.

The Ovalbumin Patent Fight and What It Tells Us About Where Precision Fermentation Is Going

By | May 22, 2026

The Every Company and Onego Bio are now fighting over recombinant ovalbumin in courts on two continents. The way this case resolves will shape how broadly IP rights can be enforced in precision fermentation, and what that means for the rest of us building this industry.

Living with a Mechanical Mitral Valve and Warfarin: The Diet, the Biochemistry, and What Nobody Tells You Until It’s Too Late

By | May 15, 2026

What I wish someone had handed me on discharge day: the biochemistry of warfarin and vitamin K, the food atlas, the drug and herbal interactions, travel, and the daily operating procedure of life on warfarin with a mechanical mitral valve. Written engineer-to-engineer.

Running a 5-Litre Lysine Fermentation From Scratch. Everything Nobody Tells You

By | February 19, 2026

If you’ve ever read a paper on lysine production with Corynebacterium glutamicum and thought “right, but what do I actually do on Monday morning when I’m standing in front of the bioreactor” — this post is for you. I’m going to walk through the entire process of setting up and running a 5L bench-scale fed-batch… Read More: Running a 5-Litre Lysine Fermentation From Scratch. Everything Nobody Tells… »

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

By | January 25, 2026

A bioprocess engineer’s journey into machine learning and why the pharmaceutical industry desperately needs this bridge When I tell people I work in bioprocess engineering, I usually get blank stares. When I explain that I help manufacture proteins in giant tanks for therapeutic use, the response is often: “Oh, like brewing beer?” Not quite. But… Read More: How I Built a Machine Learning Tool to Predict Drug… »