Single-cell RNA sequencing is one of those techniques that generates a huge amount of data and then demands a huge amount of effort to interpret it. You run the sequencer, get a matrix of 20,000 genes by several thousand cells, and then spend the next several days (or weeks) figuring out what’s in there. I… Read More: I Built a Single-Cell RNA-seq Pipeline That Writes Its Own… »
A small, cracker-themed block puzzle I cloned and polished for my four-year-old — built in plain vanilla JavaScript with synthesised audio, a Three.js bloom backdrop, and a deliberately forgiving combo system. Free to play, open source on GitHub.
I rebuilt two published CHO cell-culture papers — a hybrid ODE + machine-learning growth model, and a genome-scale metabolic reduction pipeline — as an interactive digital twin that runs in the browser. Here’s how it works, what’s under the hood, and an honest take on what it’s good for. No hosted version yet; the code is on GitHub and a live instance is coming soon.
The Every Company and Onego Bio are now fighting over recombinant ovalbumin in courts on two continents. The way this case resolves will shape how broadly IP rights can be enforced in precision fermentation, and what that means for the rest of us building this industry.
What I wish someone had handed me on discharge day: the biochemistry of warfarin and vitamin K, the food atlas, the drug and herbal interactions, travel, and the daily operating procedure of life on warfarin with a mechanical mitral valve. Written engineer-to-engineer.
Three months ago I started building an Android app to count cells. Today the first public build is up, and I’d like to introduce it properly. It’s called CellSeg, and it does one stubborn small thing: it lets a bench scientist take a picture of a microscopy sample with their phone and get a cell… Read More: CellSeg v0.1.0 is out »
I had severe mitral regurgitation and a blocked coronary artery. On 22 April 2026, surgeons at Royal Papworth replaced my mitral valve with a mechanical prosthesis and bypassed the blocked artery. This is what happened before, during, and after — medically and emotionally.
There’s a thing that happens in a tissue culture lab that I’ve never quite gotten used to, even after years of doing it. You pull a sample from a flask or a bioreactor, you load it onto a counting chamber, you put your eye to the microscope, and then you spend the next several minutes… Read More: The bench problem that wouldn’t go away »
The Corpus Clock sits at the corner of Corpus Christi College, Cambridge. Unveiled in 2008 by Stephen Hawking, it was designed by inventor John C. Taylor as a meditation on time’s relentless consumption of life. A giant golden insectoid sculpture — the Chronophage (from the Greek chronos, time, and ephagon, I ate) — crouches atop the clock face, its jaw mechanically… Read More: Simulating the Corpus Clock: A Hybrid Dynamical Systems Model of… »
If you’ve ever read a paper on lysine production with Corynebacterium glutamicum and thought “right, but what do I actually do on Monday morning when I’m standing in front of the bioreactor” — this post is for you. I’m going to walk through the entire process of setting up and running a 5L bench-scale fed-batch… Read More: Running a 5-Litre Lysine Fermentation From Scratch. Everything Nobody Tells… »