Tag Archives: Upstream Processing

A Tonne of Duck in One Run: What Parima and Vow Actually Proved

By | July 18, 2026

The headlines led with a 22,000-litre tank and a 99% cost drop. Here is a bioreactor engineer’s read on what Parima and Vow actually proved, why the media breakthrough matters more than the vessel, and the quiet shift that turned cultivated meat into a fermentation problem.

From Lab Bench to Browser: A Hybrid Digital Twin for CHO Cell Culture

By | May 30, 2026

I rebuilt two published CHO cell-culture papers — a hybrid ODE + machine-learning growth model, and a genome-scale metabolic reduction pipeline — as an interactive digital twin that runs in the browser. Here’s how it works, what’s under the hood, and an honest take on what it’s good for. No hosted version yet; the code is on GitHub and a live instance is coming soon.

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

By | January 25, 2026

A bioprocess engineer’s journey into machine learning and why the pharmaceutical industry desperately needs this bridge When I tell people I work in bioprocess engineering, I usually get blank stares. When I explain that I help manufacture proteins in giant tanks for therapeutic use, the response is often: “Oh, like brewing beer?” Not quite. But… Read More: How I Built a Machine Learning Tool to Predict Drug… »